OHB 1.3-1.5ATA, myth o real?
Hyperbaric Medicine starts at 1.5ATA and for other authorities at 2ATA.
But it is not content to be blocked at this pressure: Hyperbaric Medicine is only called this way if pressures above 1.5ATA to over 3ATA can be handled, according to the protocols indicated to treat pathologies or injuries recognised by the authorities of Hyperbaric Medicine.
Some sellers of hyperbaric chambers at 1.45ATA (which is low pressure) claim to do medicine but in reality they are outside the field of medicine. However, they do not falsify the results. The effects of low pressure are not only proven by more than 20 years of experience and are used by specialists all over the world who have changed the lives of millions of patients or improved the performance of millions of athletes.
Hyperbaric Oxygenation (HBO) is a natural procedure and at our pressure level of 1.3ATA to 1.5ATA, it is considered paramedical or better, a pillar of wellness. Remember that wellness is only possible if there is a balance between physical activity and rest, and if we provide the body with what it needs through nutrition, hydration and oxygenation. These 3 elements are even more important today as our world and lifestyle has become unnatural. And for many we are in deficit of nutrients, water and oxygen. Moreover, all chronic or neurodegenerative diseases have in common is that they develop in these deficit conditions. For oxygen we speak of hypoxia.
In the case of water and nutrients, it is not difficult to rectify the situation, but in the case of oxygen, the only way is hyperbaric oxygenation. This is the Pranayama of Yoga but with exponent 10.
Our world (including the medical world) is manipulated by economic and political rather than ethical interests. Hyperbaric medicine and pharmaceutical companies do not look favourably on the development of low pressure oxygen therapy. Its advocates have been victims of this for years. Take the case of Dr. Marois in Canada (https://maisonsaine.ca/sante-et-securite/loxygenotherapie-hyperbare-nouvelle-arme-contre-les-maladies-neurologiques-et-environnementales.html).
It challenges the Quebec government's negative assessment of low pressure HBO. "Political and economic considerations, rather than purely scientific ones, play an important role in this controversy [between high and low pressure]. More systematic research is needed, but in the meantime, children should not be denied access to HBO (Dr. Marois treats autism among other chronic diseases, stroke, and neurodegenerative diseases)," he and his colleagues wrote in 2007 in the Journal of American Physicians and Surgeons. "The surgeries require only 10% efficacy to be approved by the US Food and Drug Administration (FDA) and Health Canada." Dr Marois' study showed that his results outperformed 90% of approved drugs. However, his studies have not been accepted and published by these same authorities.
It goes beyond that. Opponents of low pressure publish this kind of typical conclusion with the intention of discrediting it. To quote just one: "These results indicated that exposure to HBO (1.3ATA) was safe for DNA and that pre-exposure to HBO did not improve high-intensity exercise performance." in: Effects of pre-exposure to hyperbaric hyperoxia on high-intensity exercise performance (https://pubmed.ncbi.nlm.nih.gov/18296957/) But if we look at the method: "Healthy subjects inhaled 100% O2 in an experimental chamber at a pressure of 1.3 absolute atmosphere (ATA) for 50 minutes once a week for 2 weeks. "
Let’s remember that when they do serious studies on HBO, at pressures above 2ATA, it is every day, from 60 to 120min and for several weeks. You have to compare what is comparable.
Few studies have been published on low pressure because they are carried out by specialists in hyperbaric medicine, validated and published by authorities who vilify low pressure. However, we can find some references from important personalities in the world of Hyperbaric Medicine such as Efrati in Israel who dedicates his life to the development of high and low pressure therapy in an objective way:
"The minimum high pressure a patient can feel is 1.3 atmospheres, which can induce an increase of more than 50% in tissue oxygenation. Since this oxygenation can have significant physiological effects, treatment with room air at 1.3ATA is not an "ineffective treatment". At the same time, oxygenation in response to pressure above 2ATA may have an inhibitory effect or even focal toxicity. It is conceivable that HBO above two atmospheres is less effective than 1.3ATA, which explains the "unexpected" improvements in the control groups when 1.3ATA was used for sham control". In: Reflections on the neurotherapeutic effects of hyperbaric oxygen (https://pubmed.ncbi.nlm.nih.gov/24471697/).
Or this observation that is consistent with the preceding study: "Hyperbaric oxygen and hyperbaric air have been shown to have therapeutic effects and can alleviate symptoms of post-traumatic stress disorder secondary to brain injury in 5 of 5 peer-reviewed clinical trials. The use of pressurised air (1,3 ATA) as a placebo or sham in clinical trials biases the results due to biological activity that promotes healing." In: Hyperbaric Oxygen - Level B Data in Mild Traumatic Brain Injury Clinical Trials" (https://n.neurology.org/content/87/13/1400.long)
This reflection is important because many studies on Hyperbaric Medicine draw their conclusions by comparing high pressure with low pressure used as a placebo and find that the results are not significant enough. This does not prevent them from observing the improvements felt or visible by patients without scientifically acknowledging them. Dr Bennett states in his publication: "The relevance of the nature of placebo effects has become a central debate in the field of hyperbaric medicine with the recent suggestion that 131 kPa (1.3ATA) of air may be an active therapeutic intervention rather than a convenient and convincing sham." https://pubmed.ncbi.nlm.nih.gov/25596837/.
Even today, there are virtually no published studies on multiple sclerosis (MS) and HBO. However, doctors such as the American William S. Maxfield have dedicated their lives to the subject: (https://www.jpands.org/vol10no4/maxfield.pdf)
"For example, one of my MS patients could barely walk from the car park to the building, about 60 feet, before the onset of HBO. After two months of treatment, he was walking two thousand on the beach. However, his neurologist said he had "not improved" because he still had a wide gait and some minor neurological symptoms. With continued HBO, his MS remained stable. "
"I now have 20 years of follow-up of two of my first MS patients. One of them still has minimal symptoms. The other, more advanced, was told she would be bedridden in six months if she did not take methotrexate, a treatment that is no longer recommended. She chose the HBO, completed her PhD, has two children and continues to practise as a speech therapist, although she now uses a wheelchair.
However, high authorities continue to discredit low-pressure HBO: "Because of my interest in MS treatment, I joined the Gulf Coast chapter of the MS Society, and after several years of membership, I was elected chapter president in 1985. This elevation brought me to the attention of the National Multiple Sclerosis Society (NMSS). When it became known that I was advocating HBO for MS patients, the NMSS requested that I not be re-elected at the end of my term in 1986. "
The same doctor who thinks more about the well-being of patients around the world than his own business recommends in his article: "Access to HBO can be improved with the development of the portable low-pressure chamber. Patients whose symptoms can be controlled at pressures of 1.25 to 1.3 ATA can, for a moderate investment, use a portable hyperbaric chamber at home. "
To complete some references published here and there. :
"Mild hyperbaric treatment (1.3ATA) prevents the progression of type 2 diabetes due to increased oxygen concentration and blood flow in skeletal muscle." https://pubmed.ncbi.nlm.nih.gov/32092737/
"Regular hyperbaric treatment with normal air at 1.3 ATA significantly reduced blood glucose and insulin levels, increased anti-inflammatory IL-10 in skeletal muscle and down-regulation of pro-inflammatory TNFα in adipose tissue of obese rats with type 2 diabetes compared to untreated rats with the same condition" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885850/." .
"Hyperbaric oxygen therapy with relatively low pressure in the early stage can significantly inhibit the expression of extracellular histones H1, H2A, H4 and NF-κB around the lesion, reduce nerve cell apoptosis and thus play an important role in alleviating secondary brain injury." https://pubmed.ncbi.nlm.nih.gov/32705509/" https://pubmed.ncbi.nlm.nih.gov/32705509/
"As previously reported, Heuser et al. showed improvement in cerebral hypoperfusion as measured by SPECT scans in a child with autism after hyperbaric treatment at 1.3 atm;" resulting in "significant improvements in some areas were observed in the 1.3 atm and 1.5 atm groups. (...) including irritability, social withdrawal, hyperactivity, motivation, speech and sensory/cognitive awareness". https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2244616/
Actually, since there is no general publication describing the effects of low pressure on every pathology, injury or other, one could spend hours searching and finding paragraphs testifying that low pressure HBO improves the quality of life of many inflammatory, chronic, neurodegenerative illnesses, etc. because low pressure hyperbaric oxygen supplementation generates the following benefits which all participate in the prevention and reduction of these conditions: 1. regeneration (cellular, vascular, molecular controlling free radicals, inflammation, acidity), 2. energy (allowing the body more physical capacities but also concentration, memory etc.).
The difference between low pressure hyperbaric oxygenation and hyperbaric medicine is that it is not a treatment for a fixed period of time, nor is it a treatment to be performed from time to time. Its benefits only occur if you start with a shock protocol at the beginning (protocol evaluated according to the age and health of the person) and then with maintenance sessions that can be limited to at least once a week (for healthy people).
Spending one hour a week in the hyperbaric chamber is as important as spending several hours a week on sport. You have to be aware of this and organise your time.